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Cell Biol Toxicol (2012) 28:4756

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In addition, in early ring-stage parasites, PfK13 mutation down-regulated the abundance of several proteins involved in the parasite respiratory chain (Supp Table 1)

Second, the development of new drugs requires additional and more detailed preclinical and clinical studies to determine whether long-term use is biotoxic, whether the drug has adverse effects on other peripheral organs or whether the drug candidate has a real therapeutic effect on the patients