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Postmortem hepatic carnitine was reduced compared to controls (Rudman et al., 1977)

For example, one JAMA analysis found that among initially-rejected branded prescriptions (all drugs), only 54% were ultimately approved after appeals and resubmissions ( [5] )

Patients miss doses

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This strategy, commonly described as evergreening, continues to fuel debate over whether secondary patents strike an appropriate balance between rewarding innovation and delaying generic competition