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These include a lack of information on the active constituent(s) essential for efficacy, failure to utilize pharmacokinetics (PK) and pharmacodynamics (PD) for dose optimization, inadequate identification of appropriate PD markers, and a lack of integration of data from preclinical testing into trial design

10.1038/s41392-023-01430-7 37 MallatJ.RahmanN.HamedF.HernandezG.FischerM

When GLP-1 therapy is added to metformin, patients frequently experience improved A1C reduction compared to metformin monotherapy

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