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In this review, we focus on the pharmacological and nonpharmacological treatments for painful DPN and ways to optimize their effects by reducing the risk of treatment-related complications

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Even minor adverse events can lead to participant drop-out or altered responses, impacting the studys statistical power and overall integrity

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Zelniker TA, Wiviott SD, Raz I et al (2019) Comparison of the effects of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors for prevention of major adverse cardiovascular and renal outcomes in type 2 diabetes mellitus