semaglutide for liver effectively treats disease in two thirds of patients, research finds Semaglutide targets MASH molecular pathways

2026 Jan 2;10(1):e25.00236

Genistein, a soybean derivate and the most studied phytoestrogen, reduces hepatic triglyceride and serum NEFA in rodent models of MASLD by various mechanisms including inhibition of hepatic DNL and stimulation of hepatic fatty acid oxidation (160)

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In an embryofetal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075, and 0.15 mg/kg twice weekly (1.0-, 5.2-, and 14.9-fold the MRHD) were administered throughout organogenesis, from Gestation Day 16 to 50

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