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Compared with the DPP-4i group, the GLP-1RA group exhibited modest benefits in terms of the composite cardiovascular outcome including cardiovascular death, MI, and ischemic stroke

The prevalence of DM has increased due to the aging global population and changing lifestyles, currently affecting 589 million adults (2079 years) [2]

In vitro studies with ERR knockdown in LPS-stimulated BV2 microglia confirmed these findings

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Researchers also monitor tolerance or desensitization phenomena over time, as sustained agonism may reshape receptor trafficking