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How do doctors decide between prescribing tirzepatide or Ozempic

Toxicol Sci 176(2):433445

The release of mitochondrial DNA (mtDNA) activates the cGAS-STING signaling axis, which then triggers macrophages in RA to secrete tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and interleukin-6 (IL-6) [21]

Melanotan-1 activates melanocortin-1 receptors (MC1R) on melanocytes, triggering a transcriptional cascade that increases melanin synthesis for 35 days after the peptide itself has cleared