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For example, the 14,15-epoxyeicosatrienoic acid (14,15-EET) is a lipid mediator, the synthesis of which can activate downstream mGluR signaling in astrocytes

doi: 10.1038/s41598-021-00002-5 34 KirlyZ.BarnaB.KecsksA.FodorJ

Douwes J, Gibson P, Pekkanen J, Pearce N

The FAERS database also revealed 41 reported cases for semaglutide with an ROR of 11.36 (95% CI, 8.33 to 15.49) and a PRR of 11.36 (95% CI, 8.32 to 15.47), suggesting a potential causal relationship between semaglutide and NAION [98]

The largest prospective trial - a Phase I safety study initiated in 2015 with 42 volunteers - was cancelled and never published its results in a journal