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When patients were stratified by history of cardiovascular disease, the use of the GLP-1 receptor agonist-SGLT-2 inhibitor combination in patients with previous cardiovascular disease was associated with a lower hazard ratio with respect to all cause mortality (0.46, 0.26 to 0.80) than in patients without a history of cardiovascular disease (1.04, 0.64 to 1.71
But there are a lot of unknowns. If these drugs do get approved for MASH, which Sanyal anticipates could happen before the end of the year, Su wonders how long patients would need to be treated
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The timeline for semaglutide to work depends partly on how quickly someone moves through these escalation phases, with most people reaching maintenance by week 17 at the earliest
Protein becomes more important for muscle maintenance
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