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Metabolomic analysis of tumors treated with DRP-104 reveals extensive alterations, indicative of dysregulation in tumor synthetic metabolism and classical cancer metabolic pathways, including changes in glutamine metabolism and reduction in several immunosuppressive metabolites [186]

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Histone modification analyses have documented GHK-Cu-associated changes in acetylation and methylation marks on histones H3 and H4, particularly at gene loci demonstrating altered transcriptional activity

Metabolism (2004) 53(5):62431