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Taking pre workout on a completely empty stomach can cause nausea, light-headedness, and gastric discomfort in many people especially with higher caffeine doses

[PMC free article: PMC3118021] [PubMed: 20845283] (19 year old man developed fever, rash, fatigue and then jaundice 1 week after starting Hydroxycut [bilirubin 7.3 mg/dL, ALT 81 U/L, Alk P 298 U/L, protime 16.7 sec], biopsy showed scant necrosis, recovery within 14 weeks of stopping)

In clinical trials, participants began noticing changes in appetite and weight within the first few weeks of treatment

Environ Res 2021;202:111644

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