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Glucagon-like peptide-1 (GLP-1) receptor agonists are medications approved by the FDA for managing type 2 diabetes and, in some formulations, for chronic weight management

Yerba mate tea and mate saponins prevented azoxymethane-induced inflammation of rat colon through suppression of NF-kappaB p65ser(311) signaling via IkappaB-alpha and GSK-3beta reduced phosphorylation

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Optimizing dosing schedules and administration routes is critical to maximize therapeutic efficacy while minimizing adverse effects such as hypoglycemia and gastrointestinal intolerance