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5 Conclusion MIRI remains a critical clinical challenge, largely driven by oxidative stress

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Doses above 5 mg/kg risk toxicity, including methemoglobinemia or serotonin syndrome, especially with serotonergic drugs

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HYGIENE A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS A61P3/00Drugs for disorders of the metabolism A61P3/08Drugs for disorders of the metabolism for glucose homeostasis A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g