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In the key Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron 36 mg produced mean body weight reductions of 11.2% at 72 weeks in adults with obesity, with nearly 55% of participants achieving at least 10% weight loss and 36% achieving 15% or more

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Both medications are typically administered as once-weekly injections, providing convenience and ease for our patients

"They may advise you to restart on a lower dose or adjust your plan to reduce the risk of side effects," he explains