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This approach captures the broader diagnostic categories (e.g., E11.1 was reduced to E11), ensuring that key information is retained without overcomplicating the model with finer diagnostic subcategories that may add redundancy or noise to the data

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Because AOD-9604 acts via adipocyte-specific pathways, primary adipocytes or 3T3-L1 differentiated cells are typical matrices of choice

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Obese individuals often exhibit both elevated NNMT in adipose tissue and impaired muscle regenerative capacity a connection that NNMTs dual tissue effects could help explain