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doi: 10.21037/dmr-23-3 44

GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically

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Kim, C.H

Do not throw them in household waste or flush them down the toilet, as this can harm the environment