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Importantly, the cardiometabolic improvements seen during treatment such as healthier blood pressure, cholesterol, and glucose levels also reverted toward baseline after withdrawal

Avoid repeated freeze-thaw: each freeze-thaw cycle creates ice crystal shear stress on the peptide backbone and concentrates solutes during freezing, accelerating aggregation and oxidation

This process helps reduce the number of calories absorbed from fat, aiding in weight loss

Anyone with uncontrolled diabetes needs to monitor blood glucose very closely given the competing effects of GLP-1 agonism (glucose lowering) and growth hormone (potential glucose raising)

10.1016/s0006-291x(03)01103-3 Biochem