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Patients in Canada, the UK, and many European countries pay far less for the same medication

The American Diabetes Association (ADA) Standards of Care notes this concern with rapid glycemic improvement generally, though the current US Prescribing Information for tirzepatide does not contain a specific warning about diabetic retinopathy complications

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Additionally, it participates in amino acid transport pathways

The region is obviously physically removed from the Middle East, but there are also many large commodity exporters, and a lot of the discussions were around the political realignment with the U.S