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Beyond its role in sleep, DSIP has been studied for possible interactions with stress response, metabolic processes, and neural signaling

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5 The role of hydroxychloroquine and its interaction with doxycycline in these cases cannot be completely ruled out, as cutaneous hyperpigmentation induced by hydroxychloroquine has been described in 13% of treated patients, mainly as a bluish-grey pigmentation, 7 mostly localised at the hard palate, gums, face, and pretibial area