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In order to replenish GSH, GSSG is reduced back to GSH by glutathione reductase

To validate the protein network analysis and further characterize influenza-induced changes in metabolism, we quantified glucose, pyruvate, glutamine, and palmitic acid oxidation as previously described [14]

Targeting inflammasome activation, inhibiting caspase-1, employing anti-inflammatory agents, and modulating the gut microbiota and bile acid metabolism represent promising avenues for developing novel treatments for this common and potentially life-threatening condition