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Data availability All datasets are available from the corresponding author on reasonable request

This population-based cohort study was approved by the Institutional Review Board of Seoul National University Hospital (IRB number: E-2104-195-1214)

Alzoubi KH, Rababa'h AM, Owaisi A, Khabour OF (2017) L-carnitine prevents memory impairment induced by chronic REM-sleep deprivation

This sensation normalizes by week 46 once your brain's appetite-control circuits fully activate and you psychologically adjust to eating less

Efficacy Context: Clinical trials for combination therapies like naltrexone-bupropion or phentermine-topiramate typically show weight loss in the range of 510%, compared to 15% or more often seen with semaglutide in similar timeframes (Liu et al., 2024)