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There hasnt been extensive research on vitamin B12 to treat sciatica, but at least one study has shown promising results

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Stem Cell Mobilisation, Scar Reduction & Multi-System Repair (PubMed, 2012) A comprehensive review of TB4s biological properties confirmed it is released by platelets, macrophages, and multiple cell types following injury, where it protects tissues from further damage while reducing apoptosis, inflammation, and microbial growth

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