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Clinical trials have shown that Tirzepatide can lead to substantial weight loss, often exceeding 15-20% of body weight, especially when combined with a healthy diet and exercise

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Taken together with the findings that utilization of esketamine as an antidepressant increases LAC levels [59], the fact that the decrease in LAC levels in subjects with MDD is independent of psychotropic drug treatment raises the possibility that increasing LAC levels may be needed to induce antidepressant effects

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