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If you ever feel worse after a B12 injection, the cause is most likely not the B12 itself, but some troublesome excipient

Mild, transient fluid retention/edema and joint or muscle pain, each reported more often on MK-677 than placebo in the same trial, linked to elevated GH and IGF-1

Inject slowly into the peptide vial: Direct the stream of liquid gently down the inside wall of the vial rather than directly onto the lyophilised powder, to minimise foaming and potential denaturation

doi: 10.1016/j.regpep.2013.03.026