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PMID 18950853), randomized 203 obese patients to receive tesofensine 0.25 mg, 0.5 mg, or 1.0 mg daily, or placebo, for 24 weeks

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Complimentarily, its ECD folded down towards the TMD to stabilize the complex with a buried surface area of ~1500 2 , remarkably higher than that of peptidic ligands

Scand J Gastroenterol 39(4):353358

It is a super versatile polymer (molecule from repeated subunits) and when it comes to cosmetics, it is often referred to as microbeads