It encompasses several pathways, including neurological (vagus nerve), hormonal, immunological, and microbiome-mediated signals, all of which play a critical role in maintaining physiological homeostasis and responding to systemic stresses (Sasso et al., 2023)
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MastrulloVvan der VeenDRGuptaPMatosRSJohnstonJDMcVeyJHet al
Conceptually, these pathways should be viewed not as isolated modules but as an integrated redox defense network, in which failure of one arm can be partially compensated by the others until a critical threshold of lipid peroxide accumulation is exceeded