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In a randomized, double-blind, placebo-controlled trial of 100 patients with episodic migraine and DAO deficiency, DAO supplementation before meals modestly reduced the mean duration of migraine attacks.59 The authors concluded that one month of DAO supplementation showed a positive trend, while calling for longer and larger studies

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If a protocol calls specifically for isolating GLP-1-only effects, semaglutide alone is the cleaner tool

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