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Second, the cycling recommendation, 8-12 weeks on followed by a 4-week off period, is based on the general principle applied to peptide therapies to prevent receptor desensitization and to allow assessment of lasting effects, rather than on direct MOTS-c cycling data

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Informed decisions support safer purchasing and responsible medical usage practices

I think Sam Altman actually talked about this publicly

Patellar tendinopathy is a common injury in sports predominantly involving jumping and landing, and results from overuse of the patellar tendon