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52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA
It serves as a coenzyme in over 100 enzymatic reactions, most of them involving amino acid metabolism, neurotransmitter synthesis, and glycogen breakdown
Providers increase the dose when one of three conditions is met: the side effects at the current dose have become manageable, weight loss has plateaued below the patients goal, or enough time has passed under the titration protocol to safely advance
Over weeks and months, this naturally leads to a meaningful calorie deficit without the psychological suffering of traditional dieting