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reported the potential of KM1468, a monoclonal antibody against IGF-I and IGF-II that inhibited the development of new bone formation and the progression of existing bone tumors (184)

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476 If SGLT2 inhibitors and GLP-1RAs are effective in patients with heart failure (regardless of whether the ejection fraction is reduced or preserved), the commonalities between the two types of heart failure may be greater than is often thought

By simultaneously targeting appetite regulation, satiety, gastric motility, and central reward pathways, they produce clinically meaningful and sustained weight loss