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Cyclooxygenase enzyme inhibition increases AA levels, which can prompt the conversion of sphingomyelin to ceramide, which is a well-known mediator of apoptosis (Chan et al, 1998)

SS participated in the design and finalizing the manuscript

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however, it has certain limitations in terms of side effects and a limited therapeutic window ( As a continuation to researches concerned with natural compounds, phytic acid (PA) was evaluated in this study in APAP induced hepatoxicity based on its antioxidant properties and its ability to modulate iron metabolism

These findings underscore GAS5 and H19 as pivotal molecular nodes in both hypertension-induced vascular remodeling and lung cancer progression [99, 102,103,104,105,106]