Extended use isnt well-studied in humans, so most experts recommend cycling it, typically 48 weeks on, followed by a few weeks off, to support safety and effectiveness.
In addition, people who have pernicious anemia (a condition caused by autoimmunity to stomach cells that produce intrinsic factor), celiac disease and other illnesses of the small intestine, those who have undergone gastrointestinal surgery, and vegans/vegetarians are also at risk for vitamin B12 deficiency
You can restrict calories all you want, but if your liver lacks the nutrients to process fat efficiently, your body stores what it should be burning
The most plausible explanation is that the non-responders used incorrect administration of the nasal drops
-- ConsumerLab.com Tests Lipoic Acid Supplements for Quality, Identifying Top Picks White Plains, New York, December 6, 2016 Alpha-lipoic acid supplements may improve insulin sensitivity and blood sugar control in people with type 2 diabetes, reduce symptoms of diabetic peripheral neuropathy, and enhance weight loss when dieting
