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Activated caspase-8 can either directly cleave and activate executioner caspases, or in many beta cells, cleave the BH3-only protein Bid to produce tBid, which is transported to the mitochondria and potentiates the intrinsic pathway, a kind of crosstalk [99]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 168.Fulci C., Rotili D., De Luca A., Stella L., Morozzo Della Rocca B., Forgione M., Di Paolo V., Mai A., Falconi M., Quintieri L., et al

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