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Without adequate glutathione, the mitochondria sustain heavy oxidative damage and lose their ability to produce ATP

Hyponatremia and hypernatremia (sodium imbalance) Sodium abnormalities typically only occur when significant vomiting, diarrhea, dehydration, or excessive water intake accompany GLP-1 RA use

Secreted GLP-1 then impedes gastrointestinal motility at the level of myenteric neurons by inhibiting downstream signaling of nitric oxide and cyclic adenosine monophosphate (cAMP) dependent pathways that inhibit vagal activity [10]