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In old animals, both high-dose paraxanthine and caffeine significantly reduced escape latency compared to control, while a trend was observed for low-dose paraxanthine

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Although more studies aimed at demonstrating other associated pathogenesis of CMD is important, a good understanding of the link between oxidative stress and CMD opens new therapeutic horizons in the management of CMD by targeting one or more specific pathways in the pathophysiology

10.1039/d1fo04239d 280 ZhengH.JiangL.TsudukiT.ConradM.ToyokuniS

BMC cancer (2021) 21(1):174