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Since immune cell trafficking into the CNS is tightly regulated by the blood brain barrier which selectively only allows entry of immune cell subsets required for immune surveillance (80), it remains unknown if CAR-T would efficiently reach senescent cells in the brain parenchyma

Micro-dosing just means using smaller doses than what's recommended by the company when you read the package insert

after the end of the study, 5 (38%) had stable disease (6 weeks after treatment), and the other 8 had disease progression, with the median time to disease progression of 51 days

Jelovac N, Sikiric P, Rucman R, Petek M, Marovic A, Perovic D, Seiwerth S, Mise S, Turkovic B, Dodig G, Miklic P, Buljat G, Prkacin I

Keep a running mental tally of unrefrigerated time