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Mechanistically, autoantibodies and Interferon (IFN)- present in the serum enhance the binding of the transcriptional repressor cAMP-responsive element modulator alpha (CREM) to the GPX4 promoter, inducing neutrophil ferroptosis

References: Krinsky DL, LaValle JB, Hawkins EB, et al

This action may contribute to improved overall health and a reduced risk of inflammatory-related conditions

Since the current study collected serum on day 1, this may indicate that the increase in TCA occurs early and then cysteine is utilized for glutathione synthesis rather than for taurine biosynthesis, which results in decreased concentrations of the taurine conjugates

Optimizing the modified GPx-DTNB assay This study used the BoxBehnken design (BBD) and response surface modeling (RSM) (Haque et al