Patients should never double up on doses or take extra medication to compensate for missed doses, as this increases the risk of adverse effects without providing additional therapeutic benefit
Once she reached her goal, she had the discipline to stop
The Real Problem: Mast Cell Activation If histamine is the flood, mast cell activation is the broken dam
Since setmelanotide and bivamelagon achieved dose-dependent weight loss in general obesity, target invalidation is an unlikely explanation for this discrepancy (NCT02041195, NCT02431442, NCT06040372) (85, 90, 101)
CPT code 99212 requires straightforward MDM (one self-limited problem, minimal data, minimal risk), while CPT code 99213 requires low-complexity MDM (prescription management, lab review, or multiple stable conditions)