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Both STZ-induced diabetic mice and the RTECs of diabetic patients express higher levels of TIPE1, and renal damage and renal mesenchymal fibrosis are lessened by tipel-specific silencing[38]

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However, the influence of high-altitude factors may cause an increase in the bodys production of oxygen-free radicals or a decrease in the speed of scavenging oxygen-free radicals, which will cause oxidative stress [18,19,20,21,22]