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However, unlike DEM which depleted GSH in a specific manner, these agents interact with sulfhydryls from proteins, leading to impairment of vital cell functions

Taken together, these findings emphasize that gut-derived microbial metabolites play critical roles in modulating BBB integrity, suggesting promising avenues for therapeutic intervention in neurological conditions associated with compromised barrier function

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In bacteria, the theta class GSTs includes all of the currently known bacterial glutathione transferases