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These tissue clocks orchestrate rhythmic expression of genes involved in glucose and lipid metabolism, oxidative stress responses, bile acid synthesis, and inflammatory signaling (1113)

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Also, in contrast to glutamate, aspartate cannot sustain its own uptake in cultured astrocytes by oxidative metabolism (Peng et al., 2001), as it should have been able to do in order for the subsequent oxaloacetate-to-malate reduction suggested by LaNoue et al