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PLP is a cofactor for the synthesis of several neurotransmitters including serotonin, the catecholamines dopamine, norepinephrine, and epinephrine [critical enzyme is aromatic L-amino acid decarboxylase (AADC) which is encoded by the DDC gene and is more commonly referred to as DOPA decarboxylase], and -aminobutyric acid, GABA (critical enzyme is glutamic acid decarboxylase, GAD)
Because supplements and medications are often processed by the same pathways in the liver and gut, the risks are similar
Just molecular mechanisms doing their job
Paris 6 , 297333 (1886)
The 2 circled hydrogens are lost and replaced by double bonds when ascorbic acid is oxidized to dehydroascorbic acid
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