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Finally, after an omics biomarker is discovered and analytically verified, the biomarker or pattern of biomarkers needs to be further evaluated in additional nonclinical and clinical studies to determine time domain, limitations of use and whether they are truly translational

We excluded participants who left at least 1 TTO or VAS question blank or incomplete (noncompleters) and respondents who reported the same answer for all TTO scenarios (nontraders)

Directionally, these findings in obese monkeys reflected the above observations in obese mice

Nausea: This is one of the most frequently reported side effects