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Melanogenesis Pathway Research MC1R activation on melanocytes upregulates tyrosinase via cAMP / PKA / CREB signaling and shifts the eumelanin-to-pheomelanin ratio in cultured melanocytes and rodent skin preparations

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The addressable obesity patient population conservatively estimated at 800 million people globally with BMI above 30, and considerably more when including the overweight population with comorbidities that justify pharmacotherapy dwarfs the T2DM market

doi: 10.1016/j.diabres.2023.110945 2 OgurtsovaKda Rocha FernandesJDHuangYLinnenkampUGuariguataLChoNHet al