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This could explain why the lymphoid cell lines are more susceptible to polyphenol/topoisomerase II inhibitor treatment compared with the myeloid cell lines

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For example, with linoleoyl-CoA (illustrated), three cycles of oxidation yield a 3 Z ,6 Z 12:2 intermediate, which must be isomerized by an enoyl-CoA isomerase to 2 E ,6 Z -12:2-CoA