what semaglutide is best Tirzepatide vs. Semaglutide: You Should Know Semaglutide vs Tirzepatide: Best Weight

A provider familiar with both medications and midlife hormonal health is the best resource

Current evidence suggests that most patients regain significant weight within one year of stopping semaglutide, indicating that this is likely a long-term or indefinite therapy for obesity management rather than a short-term intervention

Your provider might adjust your dosing or explore alternative treatments based on your liver enzyme levels and overall response to the medication

MASLD is associated with altered levels of adipsin and plasminogen activator inhibitor-1 (PAI-1), whereas adipsin is markedly higher in obese MASLD patients than in normal-weight individuals (190, 191)

Semaglutide works best when used consistently over many months