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These figures are from controlled clinical trials of the FDA-approved branded medications (Wegovy, Zepbound), combined with diet and exercise

In fact, many patients report that the initial side effects diminish significantly after the first few weeks of therapy, as their bodies adapt to the medication

Initially approved for type 2 diabetes (T2D) treatment, they were later found to influence appetite regulation (145, 146) by regulating activity in hedonic brain regions like the insula and orbitofrontal cortex changing food preference (147), therefore, leading to their approval for obesity and diabetes management (148150)

People already questioning whether they can lose weight on semaglutide without exercise or whether the medication is right for them may incorrectly conclude that semaglutide is ineffective when the real problem was a warm shipment