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Anti-Inflammatory and Antioxidant Effects GHKCu exhibits potent antiinflammatory activity, lowering key cytokines like TNF and IL6 while suppressing NFB/p38 MAPK signaling in multiple cell and animal models

Following entry into hepatocytes, Cu(I) binds the initial acceptor GSH, which delivers it to the different copper chaperones, such as Atox1, CCS and COX17 that partition copper into distinct intracellular compartments [116]

10.1016/j.physbeh.2020.113236 228 YangY.ZhouH.LiuW.WuJ.YueX.WangJ.et al (2018)

GHK-Cu operates at the tissue repair and collagen signaling level