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These symptoms typically remain mild at the 2mg dose level

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Consequently, this prolongs the feeling of fullness (satiety), reduces appetite, and reduces overall calorie intake subsequently leading to negative energy balance and weight loss 18

In conclusion, the experimental data are well described by the model for all knock-downs, except for slight deviations for siKEAP1, where the increase in Keap1-GFP and Srxn1-GFP after DEM exposure was underestimated by the model