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Animals were allowed access to water ad libitum and fed on a standard dry diet (Formula 2050 containing 20% crude protein, 5.4% fat, 40.1% carbohydrate, 8.1% crude fiber, 18.4% neutral detergent fiber and 6.1% ash - Teklad Diets, Madison WI) supplemented with biscuits and fresh fruits

Frequent Waking : Waking up in the middle of the night due to discomfort from sweating

Noticing hair thinning, dry skin, or feeling cold often (thyroid flags)

Grade C (expert consensus): Recommendations derived from expert committee reports, professional consensus statements (e.g., ADA, ISPAD), Narrative reviews and clinical expertise in the absence of robust experimental data

Author group for PIIS0140-6736(21)01443-4